|
Neonatal abstinence syndrome secondary to infant opioid infusion
| | bet | 372/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Neonatal abstinence syndrome secondary to infant opioid infusion:
-
If weaning from prolonged intravenous morphine (> 4 days), commence oral morphine using the oral:IV ratio of 2:1 (estimated oral morphine bioavailability 48.5% in neonates) [1]. So the daily oral dose is twice the daily intravenous dose of morphine.
-
If weaning from intravenous fentanyl infusion, we recommend converting the total daily fentanyl dose into the equivalent intravenous morphine dose using the conversion ratio fentanyl:morphine of 1:10 (1 microgram of IV fentanyl is equivalent to 10 microgram of IV morphine) [21]. Convert the intravenous morphine dose to oral morphine dose using the ratio 1:2. That is, oral dose is twice the IV dose.
|
| |
